Another thing you can do if you are still worried is increase your swap file size, Claymore recommends 16 GB when running his software although I never seen it use that much even when initializing. However, by doing this you would bring the total usable memory by the system to around 20GB (I say around because again Windows, it will be 19.xx something).
Now this was the answer I was looking for!!! Thanks a lot. Great answer. This I can actually work with. Howmuch is ''several 1080ti's'', though? Anyway, this is a real answer that I was looking for. I was about to say I will be using mostly Claymore as well and Skunk.
The largest 1080TI rig I run has 6x cards, the smallest 4x cards. All of them use < 2 GB RAM when mining, and most of that is actually reserved by Windows as the actual miner software itself is only utilizing a few hundred K of memory. Of course you do need Windows and drivers, etc loaded into memory too, so sticking with the ~ 2 GB figure seems pretty accurate, meaning a 4GB stick is plenty. Again with virtual memory (swap file) set to an appropriate size you are covered in any event.
Update, I also verified when mining Signatum (Skunk) that memory does not increase at all, stays right around that same 1.7 GB number. I also watched as Claymore initialized and generated the DAGs, no appreciable difference in system memory utilization, again I stand by my 4 GB is plenty recommendation.