in p2pool/p2pool/networks.py look for PERSIST=True, and change that to PERSIST=False, then restart p2pool
This will not help his p2pool installation in finding any peers
The PERSIST=False thing is only useful when you're bootstraping a new p2pool network (newly added network parameters, first node beeing setup).
It will make his p2pool setup a standalone node, but then why not just solo mining ?
By just using p2pool, you'll "force" your miner to find shares/blocks faster, due to the share delay behaviour ; if you plan to solo-mine, just running a solo p2pool node with no peer will not benefit you in any way, quite the opposite actually.
@zhongfangcai : what network parameters ("coin") are you using ? What p2pool fork (if you're using a forked p2pool) ?