Yes - and with any bank really. You always have the govt. guarantee of course, but that's also just a piece of paper..
But there's a certain degree of trust. Some institutions have a higher degree of trust than others.
So whereas you might give more trust to an established player in the bitcoin exchange market, a newcomer operated out of the shadows might be less trusted.
i guess within the next 1-3 years we will have alot better exchanges that are more trustworthy. maybe circle is the first one.
and in the long run people want exchanges or depots with insurance over their funds.