Yes. SegWit2x coins will be owed to the lender when the fork occurs. Because of this, it will be as if you are shorting SegWit2x coins.
You can read more about it in their statement:
Specifically, in the case of a hard fork event, lenders will receive both BTC and B2X. Anyone that is short BTC/USD or long any BTC trading pair (ETH/BTC, LTC/BTC, etc.) will owe B2X to the lender, effectively making the user short B2X. An exception is being made where BTC is borrowed but is not in use as financing collateral. In that case, B2X will accrue to the lender. Users that are financed long BTC/USD or short any BTC trading pair will receive B2X.
Personally though, I would always prefer to have coins out of exchanges before the fork to be safe. In the BCH fork some exchanges took parts of their users' holdings rather than giving 100%. Having control over your coins and having to wait a little while is usually better than the risk.