Only Western powers like US could use a nuke in West Asia and if they do, it would start a global nuclear war that mean nukes detonating in every major state. In such a scenario "air pollution" would not even be among the top 100 concerns of human race.
No one talks about it, but Israel does have nuclear weapons, they killed a US president to make sure no one got in their way of obtaining them. It's the most well-know "secret" in global politics.
If you think they wouldn't use them you're underestimating how evil Israel really is. They even have a name for it, the Samson Option. They would literally nuke themselves (after mass evacuations, of course) rather than let the Palestinians benefit from the infrastructure they've built with American tax dollars. As a side benefit, they would kill millions of Palestinians as a going away present. American tax dollars would then be used to rebuild Palestine, making even more money for the globalist banks and defense contractors, i.e. supporters of Israel. And since it would be Israel nuking itself, there's little fear of retaliation. Who's going to retaliate, and against whom?
If the US and Europe ever cease support of Israel, I would be surprised if they didn't pull such a stunt... And blame Iran.