I set all my 741s to -2 because it makes so little difference to the actual TH but it makes a HUGE difference in the power utilization and the sound. I loose about 1TH by setting it to -2 versus 0.
The power is 150W less at -1 and the noise goes from just about 59dB to high 40's (at 3 feet). This is a huge difference in a home environment.
(Sure, if I had a data center, a dedicated soundproof room, or even a wife that did not care, I'd have a bunch of craptastic S9s whining away and my Avalons would be running at +1.)
With four 741s at home the -2 makes life much better and the wife approval factor is much better. (At least it was until BTC went below 9K! -- "No really, honey, it will go back up - way up!"
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