It's hard to answer this question because the right thing to do is study the project, components, and only manufacturers and a couple of specialists can answer correctly, but we can try, based on experience and good sources of reliable information (like here in this forum)
If you modify the bios, you will change the straps, and you'll probably do the maximum overclock you can achieve, so it's above the manufacturer specs (already tested and realiable to sell and lasts some years), it's unknow territory
Another thing is you'll probably do undervolt and run in a good temperature, so you'll run 24 hours but with lower specs of standard, this is good
As we can see here in forum, we have users still using hawaii cards R9 290, Polaris cards modified (RX 470, 480 etc) and it's running for years, so it's pretty safe to do and run 24h
You have to consider some things: Take care when flashing the bios, be sure it's the right version, best to do with dual bios cards and there's a chance to brick your card, it's hard, but it's real and can happen
You'll also lose warranty, unless manufacturers don't have the tools to check if you change the bios.
You don't have to be a specialist to flash the correct bios for a certain graphic card it's easy as piece of cake, you can also use Hive OS, this mining OS have inbuilt bios flasher and it will recommend the best safest Bios for your graphic card, I guess this is safer than other methods out there