this is not a problem unique to bitcoin. have you ever heard of bernie madoff? mf global?
to protect against this, there are laws requiring segregation of customer's funds. this should be something easily verifiable (though this week's discovery that pfg best's ceo had stolen these segregated funds shows even those laws don't eliminate the risk of losing money to fraud).
the general advice is to never store with an exchange more than you can afford to lose. consider which jurisdiction the exchange is in and how difficult it is to even participate in trying to obtain recourse if there is a problem (see the bitcoinica mess as an example).
with bitcoin being something you can store securely yourself, you can lessen the chances that a major problem at an exchange becomes a major problem to you.