This is a serious issue and another indication that CEX might not be enjoying the popularity they once enjoyed among crypto users in the wake of increasing need for privacy. It could also be the reason mixers are flourishing which is in line with the reason for the creation of Bitcoin.
Increased crypto awareness is now making people know the importance of holding their keys but this is the case of strict regulation by the US SEC. Most exchanges make the majority of profit from the US market. Without the US market, many of them will become bankrupt and I think this was the case of Bittrex Global after its US arm was forced out of the US crypto market. This same thing will come upon any other exchange soon, tge best is to stay away from tgem and hold your coins with you by using a non custodial wallet, bankruptcy is very common nowadays with centralized institutions, they easily get financial problems by any chance.
Exchanges that want to operate in the US will have to comply with the regulatory laws. I think they will be fine if they allow the SEC to have access to all their transactions. Maybe in future will might have exchanges that will operate like commercial banks with the government having total control over them. Bittrex Global has given customers till December 4 to withdraw all their funds, this is the beauty of the winding up. 
