It's just a theoretical question since I don't have the money to do it ;-) However if you would built bigger mining rigs (let's say 30 - 60 cards), is it better to run small systems with 6-8 cards (Asus Prime z270, MSI Z170A, Gigabyte GA-H110 etc) or 13 gpu systems with a ASrock H110 Pro / Asus B250? You're a probably more flexible with smaller rigs regarding cards and psu but need more time to maintain the system. So what would be overall better would you say?
I own the MO B250 mining expert it contains 19 GPU lines and as of now it works with the celeron processor for my mining rig. Even 12 cards GPU MO also a fine to start a small mining rig. Please ensure that you are adding the Rx series cards such as Rx 470/580 both 4GB and 8GB are good.
This will produce almost 22 MH for mining eth with the 470 cards and 580 may give upto 30 MH.
I see above some suggested to have the best RAM and CPU. I wanna say you RAM need to have the DDR4 and above but processor does not matter to mine bro. Have that in your mind first.
I agree that processor does not matter much. But if I can spend $10usd more to get a Pentium over a Celeron, I'm going to do it. I started all of my 6 gpu rigs with 4gb ddr4 and they ran just fine most of the time ... I've since upgraded them all to 8gb ddr4, I don't notice a lot of difference. I think I see a bit of a difference when I remote into them. The system as a whole is more responsive to command. Those little upgrades only cost me a couple days of mining, so I do it.
Majority of my issues have been gpu driver crashes. Most of that came from core and mem overclocking a little too much on a specific gpu. Causes the entire rig to crash. Even if they are the same brand and model, they won't all be the same as far as how much you can overclock.
My solution to that is a switched pdu. Although it is not very necessary, if your gpu's are clocked appropriately, it gives me piece of mind. I can shut down the power to one rig and then turn it back on from my computer at work, my phone, with a laptop from anywhere that I have a connection to the internet.
All above is based on Win10 OS.