ErisX, LedgerX, Bakkt, Fidelity -- these companies are all trying to bring platforms online before the next bubble takes off. They won't create volume just by virtue of their existence, but the infrastructure being there when market hype really picks up could be a big deal.
The main question is whether there is (or will be) institutions who want to accumulate real bitcoins, as opposed to paper contracts. Physical delivery -- assuming significant bitcoin liquidity enters the futures markets -- could become a way for institutions to accumulate real bitcoin positions without ever touching unregulated OTC markets or spot exchanges.