Sure. I'd probably keep 25% on a single sig and 75% on multisig. There is evidently a trade off between distributed risk (i.e., distributed funds) and creating a situation that builds up too much risk from being too complex. I think two addresses properly safeguarded should do it?
for the 25% single. treat that as your hotwallet regular spend
for 75% the multisig. if you are the sole signer. obviously you end up putting the keys into a wallet to maybe once a month top up the single.
but because you the sole signer they all end up in one pc anyweay so spreading the keys out is less than needed (unless value risk is extensive to be worth the extra efforts)
just be sure to have a 'change' address that the remainder goes to that is a new multisig. so that you can wipe the wallet after spend and be at no key use risk. and have new private keys for the 75% hoard each time you use it (dont re-use address per spend)
where you have not put the priv keys into a online pc of the new multisig. you just make the public multisig offline to grab the public address to be used as the destination of the change.
and only reveal the private when its time to spend
that way your not having to reveal the private keys too often and only use them once.
as said. if you were to be putting those keys into a bank safety deposit box. it then becomes a hassle to do that each month. so only needed if you are going to be not touching 75% hoard that often or the amounts are just to much value to risk hoarding keys at home.
but obviously to generate these keys even before funding the addresses should be done on an offline system
..
but in short. just do what feels right to you dependant on how much value you feel is at risk and how much elaborateness you want to mitigate the risks, dependant on how awkward it would be to manage making payments each time you want to make a payment.
so think more about how your lifestyle fits your value. more then the technology capabilities.