Author

Topic: Combination of Vaccines (PFIZER and ASTRAZENECA) (Read 143 times)

legendary
Activity: 4690
Merit: 1276
I've researched the issue a lot.  You may or may not know from my previous comments that I choose some vaccines for my kid in her environment.  Well, one (BCG), but some others were given in spite of agreements between the parents and doctors to NOT do so.  I would obviously vaccinate for rabies in a situation which indicated it.  Possibly dengue fever as well with due care to avoid the 'pathogenic priming' issue.  I consider vaccine science to be legit and a powerful tool, but also a much sharper knife than they are marketed as insofar as they carry significant risks which must be analyzed on a situation-by-situation basis.  It may be a surprise to some, but I'm probably typical of a rabid 'anti-vaxxer'.

if this is true. then can you from now on stop sounding like an antivax script copy&paster. stop the conspiracy crap posts that have no merit in science. and instead research the science.

you travel down the conspiracy path of thinking things are made to purposefully kill millions. even when there is no science, math, logic or evidence of millions dying due to vaccines. its just conspiracy myth script pasting

you travel down the antivax path of 'i heard from somewhere that science says there is 0 risk, well i found someone that had a runny nose so they wrong and evil liars' the vaccine companies from day of release have always said about the allergin risk and the mild symptoms from immune response triggers and the 1in 1m risk of fatality.
and comparing all these, the odds of mild/severe illness/death/long term issues.. the vaccine is safer my many magnitudes compared to covid

and no rna from a vaccine wont change your body into a lizard. thats not how DNA evolution works(rna and DNA are different things)

Go look in the mirror and fuck off you idiot.

legendary
Activity: 4410
Merit: 4766
I've researched the issue a lot.  You may or may not know from my previous comments that I choose some vaccines for my kid in her environment.  Well, one (BCG), but some others were given in spite of agreements between the parents and doctors to NOT do so.  I would obviously vaccinate for rabies in a situation which indicated it.  Possibly dengue fever as well with due care to avoid the 'pathogenic priming' issue.  I consider vaccine science to be legit and a powerful tool, but also a much sharper knife than they are marketed as insofar as they carry significant risks which must be analyzed on a situation-by-situation basis.  It may be a surprise to some, but I'm probably typical of a rabid 'anti-vaxxer'.

if this is true. then can you from now on stop sounding like an antivax script copy&paster. stop the conspiracy crap posts that have no merit in science. and instead research the science.

you travel down the conspiracy path of thinking things are made to purposefully kill millions. even when there is no science, math, logic or evidence of millions dying due to vaccines. its just conspiracy myth script pasting

you travel down the antivax path of 'i heard from somewhere that science says there is 0 risk, well i found someone that had a runny nose so they wrong and evil liars' the vaccine companies from day of release have always said about the allergin risk and the mild symptoms from immune response triggers and the 1in 1m risk of fatality.
and comparing all these, the odds of mild/severe illness/death/long term issues.. the vaccine is safer my many magnitudes compared to covid

and no rna from a vaccine wont change your body into a lizard. thats not how DNA evolution works(rna and DNA are different things)
legendary
Activity: 4690
Merit: 1276
...
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I agree about that, I'm always a person who believes that kids have nothing to do with the problems of the adults. Thus we should make a life for them where they won't worry about this problems anymore.

Surprising response.  Respect.

I've researched the issue a lot.  You may or may not know from my previous comments that I choose some vaccines for my kid in her environment.  Well, one (BCG), but some others were given in spite of agreements between the parents and doctors to NOT do so.  I would obviously vaccinate for rabies in a situation which indicated it.  Possibly dengue fever as well with due care to avoid the 'pathogenic priming' issue.  I consider vaccine science to be legit and a powerful tool, but also a much sharper knife than they are marketed insofar as they carry significant risks which must be analyzed on a situation-by-situation basis.  It may be a surprise to some, but I'm probably typical of a rabid 'anti-vaxxer'.

legendary
Activity: 3766
Merit: 1217
This seems very utopic to be honest, as far as I heard the Pfizer/biontech vaccine cost around 20$  while the Astrazeneca one costs only 2$. With such huge differences in prices the production of the two vaccines must be completely different. Also the vaccination is being organised by the government's who will buy bulks of the vaccine at once. For logistical purposes it's best to stick to one type.

Let's say you are thinking about purchasing a phone. You have two options. The first one is to go for iPhone 12 Pro, which will cost you around $1,000. The second option is to go for a cheaper phone with the same specification, from either Xiaomi or Samsung. The second option would be cheaper. But do you expect the phone to be as efficient as the Apple phone? Same is the case between these two vaccines. The first one is having an efficiency of 95%, while the vaccine from Astrazeneca has only 62% efficiency. If you get vaccinated using the Pfizer vaccine, there is only a 5% chance of getting infected. It increases to 38% with Astrazeneca. 
full member
Activity: 1148
Merit: 158
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...

The only thing who have proven nothing in this era are the anti-vaxxers who are just there, whining on how these vaccines are making human bodies weak.

Vastly higher mortality for African kids who got DTP in following years compared to those who did not:

http://vaccinepapers.org/wp-content/uploads/Introduction-of-DTP-and-OPV-Among-Infants-in-an-Urban-African-Community-A-Natural-Experiment.pdf

They died of 'Diphtheria, Tetanus, and Pertussis' at a lower rate, but seemed to have been significantly weakened to the 1000s other things kids die from.  Clearly they were weakened.

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I get the sense that there are people out there who think to themselves that 'Well, yeah, maybe there are some funny things going on with shots in Africa, but they have an overpopulation problem after all so...but here in the West our Big Brother loves us and only use safe vaccines.'  Anyone who thinks like that, even unconsciously, kinda deserves whatever they get...but I do feel badly for their kids who might have grown up to be decent people if they had had the chance.



Nice study you got there, nice points to be honest, and I would not dare to counter that is research-based.

The good thing about this conduct of research is that, after the research is done, there is part in that study that states that the company who makes that DTP and OPV decrease the negative effects of the said vaccine (I guess this also results to reduce the possible protection of the vaccine, but not high that will affect the vaccine significantly.)

There is also a previous study in the research about the same topic, wherein the only rate is two-fold unlike in this study.

---

I agree about that, I'm always a person who believes that kids have nothing to do with the problems of the adults. Thus we should make a life for them where they won't worry about this problems anymore.
legendary
Activity: 4690
Merit: 1276
...

The only thing who have proven nothing in this era are the anti-vaxxers who are just there, whining on how these vaccines are making human bodies weak.

Vastly higher mortality for African kids who got DTP in following years compared to those who did not:

http://vaccinepapers.org/wp-content/uploads/Introduction-of-DTP-and-OPV-Among-Infants-in-an-Urban-African-Community-A-Natural-Experiment.pdf

They died of 'Diphtheria, Tetanus, and Pertussis' at a lower rate, but seemed to have been significantly weakened to the 1000s other things kids die from.  Clearly they were weakened.

---

I get the sense that there are people out there who think to themselves that 'Well, yeah, maybe there are some funny things going on with shots in Africa, but they have an overpopulation problem after all so...but here in the West our Big Brother loves us and only use safe vaccines.'  Anyone who thinks like that, even unconsciously, kinda deserves whatever they get...but I do feel badly for their kids who might have grown up to be decent people if they had had the chance.

hero member
Activity: 1974
Merit: 534
This seems very utopic to be honest, as far as I heard the Pfizer/biontech vaccine cost around 20$  while the Astrazeneca one costs only 2$. With such huge differences in prices the production of the two vaccines must be completely different. Also the vaccination is being organised by the government's who will buy bulks of the vaccine at once. For logistical purposes it's best to stick to one type.
full member
Activity: 1148
Merit: 158
★Bitvest.io★ Play Plinko or Invest!
only idiots take vaccines.

everybody right in mind knows that they are poisonous

and a fraud to make money and corrupt the financial systems of nations

I guess it is the other way around buddy. The very thinking of vaccines are poisonous are pretty dumb, and you must be a high school dropout with an F in chemistry and biology.

Vaccines already proved to be worthy of any kind of recognition, defeating viruses such as Polio in the planet.

The only thing who have proven nothing in this era are the anti-vaxxers who are just there, whining on how these vaccines are making human bodies weak.
sr. member
Activity: 1470
Merit: 325
only idiots take vaccines.

everybody right in mind knows that they are poisonous

and a fraud to make money and corrupt the financial systems of nations
legendary
Activity: 4410
Merit: 4766
ok. lets handle this ditty
initially they were trialing people at different doses from say 100, 60,30
the 100 group had a big antibody response and the 30 had very small response
so they gave the 30 group a second dose because the response was low. and after time they found out
the double dose out performed the other groups. its that simple

the benefits of double dosing of small amounts is less adverse affect compared to the megadose.
so it has that benefit too

..
lets explain the antibody count difference
lets say a single mega dose of say 100ul gives a response antibody production that peaks at say 100 on day 14 and then declines by 1% a day

now lets say you have one dose of 30ul that by itself peaks at 30 on day 14 and is at say 27.9 at day 21 and 25.8 on day 28
having a second dose of 30ul on day 28 then multiplies the number of antibodies already there. thus more then a 100 antibody peak (multiplying the 25.8 already in system)
and also the doses done per session are only 30ul each so 3x less of the immediate adverse effects compared to 100ul single dose

imagine it another way if a 100ul can raise temperature by 1.5oc as your body makes antibodies. then a 30ul dose only raises your temperature by 0.5oc first time.
yes the second dose due to the amplification effect may raise temperature more than 0.5oc but not as much as the 100ul. because the body has already had 2-3 weeks to train itself to not go out of control

my numbers are not exact and used only for lame brain demo explanation but the context/theory is right
legendary
Activity: 4690
Merit: 1276

Astrazeneca (a nuclear DNA treatment rather than cytoplasmic mRNA one) is trying to spin the story that they 'accidentally' gave Brits half a dose during their trials.

One of two things is true here, and none of them is good:

 - Their trials really were so shoddy that they totally messed up on the dosage!!!  I mean you'd flunk a high school class for something like this!

 - They are lying to your face (and the 'regulators' are going along with it.)

Since the whole goal of the treatment is to make misbehaving cells which pump out virus parts and have the body recognize this, the body does.  It tries to kill off the misbehaving cell since these things happen in the body from time to time and it isn't good.  The trouble with this is that the body quickly becomes resistant to the treatment and 'boosters' don't work for shit.  What Oxford 'scientists' did to counter this was to try to figure out how the body identifies and kills off misbehaving cells and stop these systems from working.  Ummm...anyone think that could be a problem in the years ahead?  Ask the Indians in a few years...if there are any left.

The technology between the two geneticlly altering methods between Pfizer and Astrazeneca are totally different.  The only rationale for mixing and matching the two would be "Fuck it.  We're flying totally blind even with the single, and if they die, well, there are too many useless eaters anyway."

legendary
Activity: 2828
Merit: 1515
sorry but this was debunked

the actual news was for those doing the vaccine organising. should make every effort to give people the same vaccine as second dose. the exception of only giving different vaccine as last resort of the same was is unavailable is just that a last resort. its an exception to the rule. not a change of rule.
the protocol remains the same. stick to the same vaccine

UK is adjusting their strategy on the 2nd doses. The original protocol was something like a few weeks from the first dose to the second -- UK is now extending that period and allowing different vaccines to be mixed in.
no.
actually try to check the source
Quote
Previous incomplete vaccination
If the course is interrupted or delayed, it should be resumed using the same vaccine but the first dose should not be repeated. There is no evidence on the interchangeability of the COVID-19 vaccines although studies are underway. Therefore, every effort should be made to determine which vaccine the individual received and to complete with the same vaccine. For individuals who started the schedule and who attend for vaccination at a site where the same vaccine is not available, or if the first product received is unknown, it is reasonable to offer one dose of the locally available product to complete the schedule
its saying try every effort to stick to the same vaccine. and then shows an example of an extreme exception to that advice. its not saying new protocol is to mix it up

What I said is in no way a contradiction of what the source said. They are changing the protocol, not making it the norm, but still a change. Is it a good idea to mix vaccines, even in emergency situations? Who knows? This is why you have clinical trials demonstrating any adverse relationships of mixing vaccines. UK is obviously not going that route.

It's not even clear how 2nd dosing works. Pfizer obviously announced how the 2nd doses and when they should be administered. Is it a good idea to make that period between the first and second dose longer?
full member
Activity: 1148
Merit: 158
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sorry but this was debunked

the actual news was for those doing the vaccine organising. should make every effort to give people the same vaccine as second dose. the exception of only giving different vaccine as last resort of the same was is unavailable is just that a last resort. its an exception to the rule. not a change of rule.
the protocol remains the same. stick to the same vaccine

UK is adjusting their strategy on the 2nd doses. The original protocol was something like a few weeks from the first dose to the second -- UK is now extending that period and allowing different vaccines to be mixed in.
no.
actually try to check the source
Quote
Previous incomplete vaccination
If the course is interrupted or delayed, it should be resumed using the same vaccine but the first dose should not be repeated. There is no evidence on the interchangeability of the COVID-19 vaccines although studies are underway. Therefore, every effort should be made to determine which vaccine the individual received and to complete with the same vaccine. For individuals who started the schedule and who attend for vaccination at a site where the same vaccine is not available, or if the first product received is unknown, it is reasonable to offer one dose of the locally available product to complete the schedule
its saying try every effort to stick to the same vaccine. and then shows an example of an extreme exception to that advice. its not saying new protocol is to mix it up

I understand everything, that this action is just a result of the a certain circumstances that the doses are not enough for the batch of patients who have taken the first shots. Regardless, if this situation occur, then the government of UK will finally decide in which actions to take. And if they do the usage of different vaccine as the second dose. Then things may happen that is not yet researched by pharmaceuticals or virology.
legendary
Activity: 4410
Merit: 4766
sorry but this was debunked

the actual news was for those doing the vaccine organising. should make every effort to give people the same vaccine as second dose. the exception of only giving different vaccine as last resort of the same was is unavailable is just that a last resort. its an exception to the rule. not a change of rule.
the protocol remains the same. stick to the same vaccine

UK is adjusting their strategy on the 2nd doses. The original protocol was something like a few weeks from the first dose to the second -- UK is now extending that period and allowing different vaccines to be mixed in.
no.
actually try to check the source
Quote
Previous incomplete vaccination
If the course is interrupted or delayed, it should be resumed using the same vaccine but the first dose should not be repeated. There is no evidence on the interchangeability of the COVID-19 vaccines although studies are underway. Therefore, every effort should be made to determine which vaccine the individual received and to complete with the same vaccine. For individuals who started the schedule and who attend for vaccination at a site where the same vaccine is not available, or if the first product received is unknown, it is reasonable to offer one dose of the locally available product to complete the schedule
its saying try every effort to stick to the same vaccine. and then shows an example of an extreme exception to that advice. its not saying new protocol is to mix it up
full member
Activity: 1148
Merit: 158
★Bitvest.io★ Play Plinko or Invest!
https://www.ft.com/content/afa31d12-c393-402b-9677-1fb312cfa1cf

Quote
"The UK has drawn up plans that would allow patients to be given different coronavirus vaccines for the first and second doses under certain circumstances, a move that highlights a widening rift in public health policy between the UK and rest of the West."

“For individuals who started the schedule and who attend for vaccination at a site where the same vaccine is not available, or if the first product received is unknown, it is reasonable to offer one dose of the locally available product to complete the schedule.”

"Mary Ramsay, Head of Immunisations at PHE, said mixing Covid-19 vaccines was not recommended. “If your first dose is the Pfizer vaccine you should not be given the AstraZeneca vaccine for your second dose and vice versa."

“There may be extremely rare occasions where the same vaccine is not available, or where it is not known what vaccine the patient received,” Dr Ramsay said. “Every effort should be made to give them the same vaccine, but where this is not possible it is better to give a second dose of another vaccine than not at all.”
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I've watched this news a while ago, and it is said that there is not much of a study regarding the effects of the mixing of two different products in a patient. The uncertainty of this action may severely damage the morality of the peoples in the UK to accept the vaccines. Given that there are many people who don't believe in it in the first place.

The action may be in the hands of the government of the UK but still, I'm curious about what might be the possible effect if these two vaccines were injected into a patient.
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