I think it's most likely life arose multiple times independantly on the early earth, but then one form was best and completely out-competed the others for resources. I've got no data for that though.
Here is something to think about. You probably learned in school that you think with your brain. signals are sent along neurons and processed by vast arrays of cells. That makes sense, but it can not be entirely correct. Consider the amoeba. It is a single celled organism with no neurons at all. Yet under my microscope I can watch them hunt, avoid things, even make choices about what to do next. How?
F#(K if I know???
Amoebas will move along chemical gradients towards food and away from deleterious stimuli. Their responses to these things are pretty much (ignoring epigenetics for now) hard coded in their DNA. They have receptors on their surface that change conformation in response to binding external molecules, the internal portion of the receptor then has a different most stable conformation and thus begins a chain of reactions (with all sorts of feedbacks) that alter the cytoskeleton giving movement. This is well known, so what exactly are you looking for an explanation for?
I also doubt that life on Earth is a One-off. Since planets and stars everywhere look similar, why should life here be special? Maybe it did not even start here.
What I want to know about the amoeba is... Is it conscious? Or perhaps, when is the benchmark of consciousness crossed? A human is clearly conscious, an amoeba could be considered to be; but what about a chemical reaction? My guess is that consciousness and what makes something alive are closely related.
P.S. Don't get me started on the epigenome! Wow, there a lot of undiscovered knowledge on that topic!
You might find the Centauri-dreams blog interesting. Not necessarily today's blog entry, but as a whole. It discusses the Fermi Paradox, the Drake equation, search for extrasolar planets, search for life in the oceans of Jupiter's moons, interstellar probes, Dyson spheres, life, etc. Read it, search it, and so on.
http://www.centauri-dreams.org/Now, regarding life in the Universe, consider the possibilities:
1. Many different kinds of life are bound to happen, given a primordial soup.
2. Just DNA life is bound to happen, given a primordial soup.
Or consider possibility three:
3. Given 500 billion galaxies, each having 100 billion stars, where it seems reasonable that a very large fraction of those stars (born out by the Kepler telescope's results) have rocky Earth sized planets in the habitable zone with liquid water, and most of those planets having a primordial soup at some point, and all those chemical reactions, that even so, the chance of the right sequence of molecular chain reactions happening to give rise to the precursor of life still turns out to be a million to one in this Universe.
Let me rephrase option 3 a little so you understand exactly what I'm saying: the molecular chain reaction to create life in this Universe happened just once, and it was a million to one against it for the entire life of the Universe. Conclusion: if you buy into option 3, life only exists on Earth, and it was a fluke.
Now, is option 3 unreasonable? No! Theories in cosmology predict that there are millions of Universes, so in at least one of them, life could've arisen once, and naturally we will be the ones witnessing it, because obviously we wouldn't be in one of those Universes where life didn't arise.
Do I believe in option 3? I consider it a possibility. I also consider option 1 and 2 possibilities.
Here's a very sobering thought, though. If we're all descendants from the same species of microscopic DNA based life, then it seems that it only happened once. Why aren't there other descendants from other primordial microscopic forms of life on Earth?
Now, let's move on to the second part: intelligent life and the possibilities.
1. Life is common in the Universe, but technology wielding life is a fluke.
2. Life is common in the Universe, and technology wielding life is common, but they never survive long enough to migrate throughout their home galaxy.
3. Life is common in the Universe, and technology wielding life is common, and they have spread through their home galaxy in a diaspora.
Consider 3. Where are they? It can be shown that even if near light speed is never obtainable, it should only take about a million years for a space faring civilization to spread throughout the galaxy. Where are they?
Let's consider the methods:
1. Superluminal speed is possible, and they can go anywhere, anytime.
2. Only a fraction of light speed is possible, and it would take several million years to traverse the galaxy. In this case, it would be about 50 years between the stars. Assuming colonies are setup along the way, they should still be here, unless their civilization fizzled. Remember, the key point is, other space faring civilizations would not necessarily have arisen coincident in time with ours. Presumably, many have arisen billions of years ago.
3. Even a moderate fraction of light speed is not possible. Consider our technology. Our fastest spacecraft would require something like 70,000 years to reach the nearest star, and it's only 4.5 light years away, as opposed to stars in our own galaxy that are nearly a hundred thousand light years away. Still, consider generation ships migrating outwards, or utilizing the resources in the Oort Cloud to hop our away across the void between the stars the way the Pacific Islands were colonized.
Do you wish to read an interesting book on the subject? Consider these two:
Entering Space: Creating a Spacefaring Civilization by Robert Zubrin
Interstellar Migrations and the Human Experience