In the early days it might have been possible to find some opportunity and arbitrage situations going on with crypto sites, nowadays however they are all using the same statistics companies to put out the same odds as fiat gambling companies. You're unlikely to find any noticeable difference. One advantage or disadvantage you might get from crypto betting is movement in the underlying asset you hold more than making money from the bets. If you're a fan of Bitcoin and a small scale gambler, maybe someone who lays their bets when they can get a nice promotion, then it might work in your favor to hold a sportsbook wallet balance which could increase in fiat terms without doing anything else. Besides that and taking advantage of different special offers, there is no noticeable difference and crypto might have a difference if exchange fees are expensive or transactions are slow.