It's safer than storing on a computer that you always use and is connected to the Internet, but that doesn't mean 100% safe. If you computer has ever been connected to the Internet then there is a risk it's compromised. Your best bet is reformatting your drive and doing a fresh install of your operating system. Linux probably works best for that since it's freely available.
Yes, but that's not really necessary. A much safer, more convenient way to back up your wallet is use one which gives you a recovery seed (password) which you can write down. See versions of Electrum for that.
Again, they're safer than ones that are not connected but not 100% safe. Think of who else might have access to that computer. Maybe they don't know money is stored there and start using it without your knowledge. I recommend using a dedicated hardware wallet for any significant amounts. Try Ledger Wallet.
Storing multiple coins securely is much harder than picking a few and just concentrating on storing those correctly or using a hardware wallet. Hope this helps!