The way it shoves everything into a narrow column in the center of my browser window.
They have succeeded in simulating watching 4:3 content on a HDTV... with webpages.
No biggie... they don't really want me reading anyway.
http://patrickkeane.files.wordpress.com/2010/04/lifehacker_alignment_pic1.jpg
The difference isn't that big. The difference isn't that they've shoved everything into a narrow column, the difference is that they've removed the unnecessary elements on the side. Do you really need to be reminded who is the editor-in-chief on every page?
Things haven't been crammed together. In fact, there is slightly more reading space than there was before. People are just way too conservative and nostalgic for their own good.