Even if you use the one full size slot directly to power one GPU you are ok without using them as there is plenty of power from the normal power connectors for one GPU and the motherboard/CPU components. With all that said, it also does not hurt to use the extra connectors if you have the cables to spare. I run several of these boards and all the GPUS are using powered USB risers so I do not bother with the on-board 4-pin molex connectors and everything has been working fine for the past 12+ months.
That's right. You are the man! I'm just trying to spoke in a general view, I mean I didn't talk about RX series or may some GTX with lower power consumption. How's if we are talking about a monster, R9 390 or may R9 295X2. That's what I mean.