I'm not sure exactly how you can go about this, but I was thinking about having players being able to choose between playing a computer or playing head vs head for selected amount of wager (.0001; .001; .01; etc.) Something similar to the popular game "8 Ball Pool" by the guys over at MiniClip, but instead of playing for their pool coins, you play for BTC.
Like I said, this is just something I would be highly interested in seeing, I would for sure play some of my personal coins on something like this
![Tongue](https://bitcointalk.org/Smileys/default/tongue.gif)