I am sure the US can exert sufficient pressure on Israel to smoke the peace pipe.
The question is, will the Jewish lobby allow them to?
I agree that the US can certainly influence Israel to go in that direction, but I wouldn't overestimate the power AIPAC holds over Washington - they have some influence, sure, but are dwarfed by the business lobbies and other powerful groups. The way I see it, part of the problem is the Palestinians simply play no important role, as far as US policy is concerned, and as far as US businesses are concerned; whether the Palestinians disappear, or some sort of peaceful accommodation is reached in the region, is of little consequence to them - on the other hand, business and military cooperation with Israel is already extensive, so either US and Israeli objectives tend to coincide, or Israel does as it pleases in affairs the US has no real interest in ...
... until someone goes and does something stupid. After Netanyahu's controversial speech last week, now it's the GOP's turn: 47 Republican Congress members submitted an open letter to Ayatollah Khamenei trying to sabota... I mean, enlighten the Iranian leadership on how the United States' constitutional system works, and how that will affect the ongoing negotiations regarding the nuclear deal. And I must say, it really is kind of backwards of the Iranian leadership not to realize how things get done in Washington: you just have to bribe - sorry - contribute to the campaigns of the right people, and everything will go smoothly - and it's pretty cheap too.
The story, as covered by TyT: https://www.youtube.com/watch?v=2JGY7g-l39A ("GOP Leaders Betray Our Country By Writing Letter to Iran", 10m36s); and TRNN: http://therealnews.com/t2/index.php?option=com_content&task=view&id=31&Itemid=74&jumival=13383 ("An Open Letter to the Ayatollah from Republicans", 10m08s)