1080Ti has about 200W TDP, and they will consume a lot of energy.
Only one 750W PSU is not enough for the rig.
Stock TDP on a GTX 1080 ti starts at 250 watts and some aftermarket cards MIGHT BE HIGHER.
I wouldn't even THINK about trying to run a pair of them on a 500 watt supply, and 2 of them + rest of system on a single 750 is going to be a bit marginal for reliability.
Existing power supplies would be enough for most GTX 1080 models (the MSI Armor has a 240 watt TDP but in my experience with one it rarely got over 200 even WITH overclocking).
G4400 box cooler is PLENTY to keep it cool - my G4600 with the box cooler in a NON A/C ENVIRONMENT runs a lot cooler than the GPUs in the system.
M.2 NVMe uses PCI-E lanes and on some motherboards may shut down one or more slots (probably NOT an issue with the motherboard OP posted though).
M.2 SATA shouldn't have that issue, but tends to be more expensive than a conventional hard drive.
IMO if you're going to go that route use a USB flash drive, plenty fast enough and much lower cost.
Windows 10 IMO is a bad choice for a dedicated miner - if you have to use Windows for mining go Win7, but better yet go with one of the LINUX-based mining distributions.