Ledger and other cold wallets such as Trezor are the most reliable crypto wallets, as hackers can't connect to them and steal your money if they don't have an access to this device as well as to your private key. So it is the best choice for crypto holders. We had better not use hot wallets especially on exchanges, as hackers can steal our money, and in terms of exchange wallets, our tokens in them belong rather to exchanges.
To be honest, software wallets can be considered similarly safe if you keep your computer clean from viruses and malware and follow general security rules. Hardware wallets of course increase the security a bit more, but you still need to keep a seed key safe. Many do this in a password manager that can also be read when the computer is inflitrated or you write the key somewhere offline and then it is destroyed by something (e.g. house fire). Then your coins are still on the wallet, but you can no longer access them.
