I made .0003635365 yesterday and am making it today and I was not using any of the multi pools listed on this page above.
I'm making it right now too mining a coin that I've let my pool members know about on our chat board..
and it's gone down - it was almost twice as much four days ago but if will go back back
being more profitable than the multi pools does require work and research and it takes times.
I've mined on IPOminer and those guys run a great pool much better than any of the other multi pools in my humble opinion.
and just remember - if your multi pool is paying in you in BTC then chances are they're dumping whatever you've mine at high bid price and a lot of times you're giving up 3% to 10% of what you could have sold the coins for yourself.
One important thing to note is that there's always a question of scale. Opportunities for mining lesser known coins or coins with higher temporary profitability are typically very short-lived, and it isn't possible to scale mining up on them. You can mine them at 10Mh, 100Mh, maybe even 1-2Gh - probably not at much more than that though. Difficulty eventually will increase to the point that they aren't profitable anymore.
And yes, as lifeforcepools says, if your pool is paying out BTC, you're losing additional profit because either they are not selling at optimal times or they're pocketing that increased non-transparent profit.
I've considered expanding ipoMiner (or starting a new service) which would payout in BTC with coins being sold in a managed fashion - but then we're getting into hedge fund type territory, and since scaling is still the primary barrier, the value for the pool operator just isn't there to support the additional time required to do it successfully. I have a few ideas of how to improve/solve that, but I'm not ready to lay all of that out yet