1) use multialgo miner (like nicehash, or any other that you can find in this subforum)
2) mine any coin based on whattomine or any similar mining calculator with highest profit for you config
3) watch the thread of new altcoins and mine it right after it launches when the difficulty is low, but there is a risk that new coin might be never listed on any exchange so you will not be able to sell it, so you need to choose it carefully and analyse technology behind it first.