Zero issues on Windows 7 and running stable for days at a time. I just installed the latest Nvidia drivers and the 1080 worked out of the box. Having mixed drivers on Linux is definitely an issue to get working though.
I'm using Windows 7
I have a primary rig that drove me crazy, so I think I'm able to to that, I spent 3 entire days working on this rig to run 100% (2 rx 580 + 2rx 570), and I will instal the 1060 with my second rig (rx 480 only)