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If it's the pros and cons of using 2FA, then I'll add another that wasn't mentioned here:
Since it's a 2/3 multisig address, your transactions will be larger in size which will make your overall transaction fee (mining fee) higher than a non-multisig Electrum wallet.
For example:
"1in-2out" (1 input, 2 outputs) TXs created by a Legacy Electrum wallet will have an average of 220vB in size.
An average legacy multisig Electrum wallet's 1in-2out transaction would be 370vB; 210vB for SegWit multisig.
While it's 150vB in average for native SegWit.
The difference isn't much for 1sat/B tx fee rate or for a 1-input transaction,
but if you need to pay 50sat/B+ or have to use more inputs, the difference will be consequential.
TL;DL: That said, at least create a SegWit Multisig wallet instead of the legacy one to save transaction fees.
But just like regular SegWit addresses, some services and exchanges still don't support them.