What I would like to see for Raspberry Pi and their cases is support for simple SSD drive installation including M.2 drives, and not doing that with USB connection or converters.
I saw some clones and alternatives for Raspberry that have this support, and one guy (mfolejewski aka Mirko_electronics) created something similar called BitPiRat.
Gen1 is done, he is now working on Gen2 with passive cooling... worth checking out this project that has specific purpose for running Bitcoin node
https://hackaday.io/project/179571-bitpirat-computer-gen1
Gen1: https://github.com/mfolejewski/BitPiRat
Gen2: https://github.com/mfolejewski/BitPiRat-GEN-2.0
PS
Enclosures STL files available for printing, so it can be fully In a Box