You'll have to define what 'lost' means to you, some consider it to be Bitcoin's that have not moved for xxx number of years or addresses whose private keys have been lost.
The latter is very difficult to prove as not all users announce publicly that they lost assess to their balance, if you chose to go with addresses that have been dormant;
• Narrow it down to only addresses that has a balance in it,
• Here's a thread from LoyceV on
List of all Bitcoin address with a balance. Data on much older addresses may be harder to find,
• Check when those addresses where last involved in a transaction and determine which time frame indicates they are lost.
Not sure if this would work, but it's worth a try.
Data on rate of Bitcoin's mines is fairly easy to get.