With regard to decreasing speeds and slot type, it doesn't matter. 1x pcie is all that's needed for mining with any gpu. You can plug a 1x -> 16x cable riser into any pcie slot and it will function fine.
firmware: These days, it's not too risky unless you lose power. However, you always run the risk of bricking a card and may have to rma it. SO have a good reason to flash. DOn't just do it because you think the newest firmware is the best.
I tried one of the add2psu modules with 2x 1600 watt psu's. It was a no go for me. One psu registered an error led when it was connected. The add2psu device isn't compatible with alot of higher end psu's that have advanced fault protection features. Best advice I can give you is to avoid that gimmicky stuff.
Thanks for the answers. I have a few followup questions.
1. Is there any difference between 280x cards from different brands? Can I expect the same performance / reliability / stability from 280x cards by different companies?
2. Can I use multiple 280x from different brands in one rig? If yes, will they need to be configured separately, for all of them to reach max potential?
3. Which brand's 1600W PSU do you use? Also, how do people use 5 or even 6 GPUs in their rigs with a single power supply?
4. What difference can I expect if I decide to go with Windows 7 instead of Linux, as the OS in my rig? I really want to stick to Linux, but most brands have Windows based tools to under-volt / over-clock cards without having to mess with the BIOS.