I would not personally choose one for self / home defense due to the size, weight, and power of the weapon system and projectile. 
A couple problems that come to my mind right away:
Cost of the gun - probably $10k+
Cost of the ammo. Expensive ammo = you won't be able to practise much.
This is a sniper rifle - useless for self defense, unless someone announces they're going to assault you and you'll set up in a window waiting for them to go through the gate. Even in such situation, a simple SMG like MP7 or Scorpion would suffice. Most people don't own properties large enough to effectively defend with a sniper rifle and small automatic weapons easily reach targets that are 100m away.
tbh, for 10k, it would probably be better to just put bars on your windows/doors, have a gate. And a security system. Or the best preventive measure, not be telling everyone what you have.
The world is so insane that you're just as likely to go to jail defending yourself while the intruder's family sues you. Esp with a sniper riffle, if they're not close enough to be an immediate threat you're screwed.
And esp with most home invasions having multiple intruders, unless you're Rambo it's best to prevent it from happening or to not piss them off. Anyone talking about a sniper riffle for home defense is going to get themselves killed, lol.
I see so many problems with this, i also think a smg would be overkill and less effective for home defense. they're not going to be wearing armor, there's probably going to be multiple, and odds are the homeowner won't have expert aim., and not more than a few feet away. 4+ shot, shotgun is all that is needed.
