What return will you be happy with?
I feel a 10x overall would be great personally but i do have a few altcoins I plan to hold longer in the hope they can 50x or more.
Since most of the coins are in the top 50, I don't consider a significant increase towards them during the bull run. At most, it will be x10, but I doubt that it will happen. I'm not focusing on the multiplier, but I set my price selling targets based on a bit of technical analysis that I've learned while watching some YouTube videos. Altcoins that are outside of top 100 will have a higher upside than those that are the top as it has a lower market cap, but it's riskier. Higher multiplier = the lower the chance of it to happen so at least be realistic on your price selling targets especially in altcoins.
On average, I think around x3 is my first selling target followed by x4 or x5 or at least around those multipliers.