Market Analyst from Matrix port states that this isn't great news, and that this generally means that large amounts of Bitcoin may be set to be sold. I'm not sure, but that usually is a big indicator.
If you look at
Bitcoin exchange balance for Binance (scroll down, select exchange) you will see there was also also a massive spike back in November last year at around $16K, very much near the lows. But within a month the coins were largely absorbed by the market with some sideways trading. So I wouldn't call it a "big" indicator. Also this uptick in exchange balance isn't really reflected by other exchanges, it's still relatively sideways and at similar lows to the start of the year, despite price increasing by 100%. If anything, taking exchange balances as an "indicator", it remains very bullish for Bitcoin.
Another point made in the article is that the increased amounts of BTC held on exchanges might renew investors confidence following the FTX collapse 'late last year' trying to make it seem like it was forever ago lol.
If you look at all exchange balance (same link) then it's still very low. Lower than it was at $25K and still lower than the FTX capitulation around November 2022. The data on that chart also only goes back to May last year.
Another chart I just found shows how overall exchange balances are still at around 2018 levels since declining in 2020. So in the short-term, this Binance deposit is a blip on the radar it seems, and doesn't reflect overall exchange balances either. The fact that exchange balances remains the same/less than when price was around $16K indicates how few sellers there are right now.