Once you figure it out, it is pretty easy to use. The ease of use is about equal to blockchain.info.
Blockchain.info is still better to use on the go though because if you want to send money from your trezor (and you are not at your computer), you have to install the browser plugin. Many public computers will not allow you to do this (by default), and many of your friends may not want you installing things on their computer.
I am a little concerned about holding a significant amount of BTC on the Trezor and then having a hardware failure, as up until this point, Wallet32 is the only wallet that you are able to restore your coins to (without purchasing another Trezor).
IMO, if you are thinking about buying a Trezor, you should consider buying 2, in case on of them fails in the future.
Electrum and armory will soon support the backup seed. Also Blockchain.info is looking into it!