As quite an early adopter of bitcoin, I know that I still value of lot of things in absolute BTC terms and not fiat terms. Gambling would be one of them.
When I'm betting with 0.01 BTC, I definitely don't feel like I'm playing with $400.
Those psychological differences definitely do add up for the casino, who ultimately profits more from it.
I have lost many bitcoins while gambling, when I consider it that gives me big chills because I am not a rich person, even one bitcoin is a lot of money for me, but I did had one bitcoin in my life, I had multiple, but I never had 40k before, so that is how I think in order to keep sane.