Everyone is indeed responsible for their own choices and they all react differently to the different outcomes of those said choices. But then again everyone is a different person with a different personality. I for example do not mind losing small amounts for fun. Because thats what gambling is to me, basically just fun. But then again, I am not someone who would bet his lifes savings for anything.
So I guess it really depends on how hardcore you are willing to go.
Of course, winning hundreds of thousands of USD is way more exciting than winning few hundred bucks, but that does anyone really care about having fun at that point? At that point its basically an obsession, unless you are rich. Then its relative fun.