Well if you keep your wallets in one place and if the malware works in a specific way, like keylogger or memory scanner, you could lose coins in all your wallets if they all got exposed to the malware.
That's not so simple, you can break your own privacy if you do similar transactions from both wallets. For example, depositing to the same exchange account.
What would you recommend then?
The only transactions I conduct with crypto is trading and gambling. I'd say 25% trading and 75% gambling.