There is no loss there really as BTC is divisible, the value is reflected elsewhere in the blockchain. Same deal as the old case of a pop band which physically burnt 1 million in british currency. The value was not lost in that example only the personal control of it by those individuals, all other notes gained a very slight amount. If BTC is lost in this more virtual case then other wallet balances will gain some value by the reduced supply, we can see this by the big amounts contained in the original wallets of founding members of BTC blockchain. If Satoshi were ever to return it would at face level and immediate terms be quite bearish and Im sure they were aware of that, the circulation of money never moved from an old wallet represents new supply though in theory it was never acknowledged as lost. There was an old amount moved recently but it was quite small in the bigger picture, still it caused some minor alarm.
https://www.newsbtc.com/2020/05/20/bitcoin-shows-weakness-as-11-year-old-wallet-moves-50-btc/