Any of the main cryptos will be profitable, middle to long term.
That said, there are better reasons than profit to divest from fiat. Not supporting state-sponsored terrorism is my personal favorite.
Some of the main cryptos will probably die or almost die so I don't know if you can say that any of the main cryptos will be profitable
BTC and LTC are good bets, there will probably also be other currencies backed by gold and backed by a trusted bank
As for BTC/LTC...I don't know, I have some LTC in case but it is impossible to mathematically predict with high accuracy if LTC is a better bet than BTC, some do think it is