"Safe gambling" can only mean one thing! If you have 1000$ in your wallet, gamble with 30$ and that is safe. You will go home with 970$ in your wallet, and if you have luck, with 30$ you will make couple hundreds. If not you had nice game, you try to make something but you didn't have luck. Try again the same for couple days, or next week.
That is the only way how can I see safe method for gambling, any other way where you sit in casino with money you have is possible chance to lose all you have. That is how casino make money on our greedy character. Play safe just means don't risk money you don't have, or last money in your wallet.
Yes, however, you need some good discipline. Because if you are not careful, you'll just gamble away your 1000$.
My best suggestion is to store most of your bitcoins in a bank wallet, which you probably won't touch unless you really need to.