Juventus will definitely win if you ask me. The only other possibility would be a draw, Roma will not even play to win, they will park the bus and just try to not lose, and Juventus only has to do is find one goal, if they can find one goal, then Roma will try to attack more and that means Juventus will be doing even better.
I hope that Roma doesn't play that defensive, it is a boring game when they do that, Juventus not being able to score would mean that we would see a 0-0 boring game without much thing. However, if we are talking about a situation that means Juventus scoring just once, then everything else will suddenly become a lot more fun instantly. That is not really that easy to do against Roma, but not impossible neither.
If Mourinho applies the bus parking strategy, it will frustrate Juventus in attacking. If you look at the situation, it looks like Mourinho will do that this time, because after all, beating Juventus by playing openly is very risky of losing points. In other words, it looks like this match will run at a slow pace, very carefully and will look a little boring.
Alleggri and Mourinho both used a 3-5-2 formation this time, I think Juventus deserves to be the favorite in securing full points. Apart from that, if Juventus gets an additional 3 points against Roma, then the point difference with Inter will be even narrower, because Inter also experienced a draw against Genoa yesterday.
Lukaku will be Mourinho hope on the front lines, Alleggri must prepare a special strategy to contain him. For Dybala this will be an emotional reunion, it will definitely be very interesting to watch this match, I won't miss it.