After today's match against Roma, they will play against Napoli in the next match. And in the next match they will face Liverpool in the Champions League. Now if Inter Milan wants to win all the matches, they will not be able to win any of them. They have to move forward with the goal right now. If they want to beat Liverpool in the Champions League, they need to rest some of their key players in today's and next match. Let's see how they perform against Roma today.
The situation is not really friendly to Inter, it is hard to have full team in all matches so they need to choose which one is their main target.
Their position in Serie A is not really safe and they are also willing to go further in the Champions league.
So it is reasonable if today they will not play with their best squad as I believe Serie A and Champions League are more prestigious for them.
I think Roma will win today as they may play with a better team than Inter.