As seen in the OP, it's about ANN meaning online (only) casinos, so there won't be a local office where users can file complaints, etc. Therefore the service is similar (I think) only payment method, currencies, promotions, and language that mainly differ between these two types of casinos. But since currencies & payment methods are pretty much not a problem for crypto users, then only "culture" (level of support, language, habit, etc.) can be tailored to match the users' location.
Thanks for the variety of insights, by the way, I learned a lot!
Promotions are nothing different for global and for local, if the local casino have A,B,C promotions while global casino have A,B,C,D,E,F,G promotions, it doesn't mean when you play in global casino, you can enjoy all the promotions.
The casino will adjust the promotion based on the player's IP address, so you might only see A,B,C promotions, the same promotion in local casino.
Payment method and the currencies are the difference that can't be denied.