Roma will not want to take any risks now. They will want to focus entirely on one side. Several important players of Roma are already injured. And so Mourinho will not want to take any risk in the match against Spezia. I guess Roma will try to draw the match by playing completely defensively in this match. The Roma team will not want to be defeated in the home match.
I don't fully understand what you mean about Roma vs Spezia. In fact the match was played after the Europa League final against Sevilla so if Roma fail to win the Europa League title to win Champions League tickets, then obviously the match against Spezia will be very important.
At the moment Roma only need to mentally and physically prepare their players to play the Europa League final on Thursday night in my time zone, so the game against Spezia will only be thought about after the final is over.
The Europa League final is very important for Mourinho. He has been fighting for the Europa League title since the start of the season. Although Roma's performance in Serie A has been erratic, Roma has played very well in the Europa League. Mourinho will try his best to win the Europa League title by defeating Sevilla.
Both teams have strugle hard to reach the final, but Sevilla's journey to the final was really tough so I believe they can win the title. Compared to Roma, I tend to believe Sevilla will win the final match this season.