The fundamental reason large traders want to find each other and trade blocks (in every market) is to avoid front running (perhaps this is what you mean by manipulation).
Let's say you want to buy 50k XMR so you start buying on an exchange, but with the liquidity there you can only buy a few thousand per day without moving the price much. Other people start seeing there is a big buyer in the market and bid the price up ahead of you. Now it costs you more to complete the trade. The same thing happens to the seller, especially if he isn't selling at the same time you are buying (and since you don't really know about each other, how would you communicate?). Let's say you buy this week and he sells next week -- in that case you will both get worse executions.
There is also the fact that trying to buy 50K on an exchange without absurd slippage might be a lot of work. If you can find a counterparty directly and just do the deal, that might be easier.
Thank you!