Even with negative house edge is difficult to make profit,because you have to know to have a strategy
moneypot has a way to have negative edge,but even that way,it is really difficult to make profit
Actually, bustabit doesn't have a negative house edge but rather makes it possible (through PvP) for players to be +EV. In many ways it's like poker, you can play poker profitably at the expense of another players, but the house isn't -EV
No one should expect a casino to offer a no-house edge any time soon (other than PvP games), as the risk is simply astronomical. Games like bustabit with a small house edge (0 to 1%) at times has been financially challenging to run, we've had a 24 hour period of time that's wiped away 3 month of profit. (Imagine a greedy player: 99.9% of the time he's going to lose, but the time he wins ... you're going to be hurt).
My intuition tells me a casino could be profitable on a 0.1% house edge, but it would require a huge bankroll to be able to support whales which often make a significant portion of a casinos profit.