Nice list. Seems that the top teams suffers at least. Chealsea, ManCity and Tottemham do not need to provide any players for the Cup of Africa.
Teams in the relegation battle are suffer at most like Leichester, Crystal Palace or Hull City. Definetely a competitive disadvantage which should be considered for the next bets.
Here are the players who will leave for the Cup of Africa: (jump about 4 matches)
ARSENAL: Mohamed Elneny
BOURNEMOUTH: Max Gradel
BURNLEY: No Player
CHELSEA: No Player
CRYSTAL PALACE: Bakary Sako, Wilfried Zaha
EVERTON: Idrissa Gueye
HULL CITY: Ahmed Elmohamady, Dieumerci Mbokani
LEICESTER CITY : Daniel Amartey, Riyad Mahrez, Islam Slimani
LIVERPOOL: Sadio Mane
MANCHESTER CITY: No Player
MANCHESTER UNITED: Eric Bailly
MIDDLESBROUGH: No Player
SOUTHAMPTON: Sofiane Boufal
STOKE CITY: Wilfried Bony, Mame Biram Diouf, Ramadan Sobhi
SUNDERLAND: Wahbi Khazri, Lamine Kone, Didier Ndong,
SWANSEA: No Player
TOTTENHAM: No Player
WATFORD: Nordin Amrabat, Adlene Guedioura
WEST BROM: No Player
WEST HAM: Andre Ayew, Cheikhou Kouyate
The leicester seems to me the most penalized team, Mahrez and Slimani out