Yes it is. The problem is convincing someone to hire you without a degree.
Important point for those considering this route.
I can only speak from the perspective of the U.S., but as a rule of thumb, if you can make someone money here they will pay you. But you have to get your foot in the door. Many professional fields are closed off by regulation. That is to say, you cannot legally practice without the right government issued paperwork, and that is impossible to obtain without a college degree. Sometimes if one is knowledgeable about, say, construction, one can get a job as a bureaucrat, but that is low paid and most who have the potential to self-educate would probably find the work unrewarding.
My opinion of education in the U.S. and in a technical field is that getting a degree proves two things. 1) one has a certain minimal intellectual capacity (e.g, can get through differential equations, etc, which is little more than an IQ test in reality.) and 2) one can stick with something for 4 years or whatever even when it is often boring and stupid and you need to deal with various levels of idiocy. Both of these are valuable to a potential employer. If one can demonstrate the ability to be of value without the degree, that is just as good (and probably better to the more dynamic enterprises.) That is usually accomplished word-of-mouth, but one does have to get their foot in the door somehow. And, of course, have the ability to be a worthwhile asset.
Most people who have the potential to self-educate would probably do better starting a business of their own. And most probably do.
---
Edit - follow-up:
A college degree means less and less as time goes by. Many people who hold a degree and a government issued license to practice actually need help doing their job effectively from someone who has a few brain cells to rub together. This is not exactly new. In the 1950's when women were more excluded and men were the 'breadwinners', it was pretty common for the secretary to be running the show in white-collar offices and the executive for whom she worked. Effectively she was basically the brains of the operation. A similar dynamic is probably evolving where college educated morons will need hand-holding in order to perform. Targeting a niche where that is practical would be a strategy. At least as a phase of a self-directed learning program. Just an idea.