No, smartcoin will run on one "master" machine. This keeps it simple as there is no need for any client-server architecture. When you add a machine through the control screen (this isn't active yet, though I've test it), you give it some information on your remote machine (host address, port, username) and it will try to make a connection over SSH, and if successful a public/private RSA keypair is generated so that the remote commands can be run directly from the master machine. There will still be only 1 database. As a bonus, the "miner" screen instance doesn't need smartcoin's monitoring functionallity to run, so if the master machine goes down for some reason, the other machines will still keep mining (though without advanced features such as failover, etc).
The architecture also allows for smartcoin to run on a computer that isn't even a miner at all (like a dedicated low-power netbook PC) and control all the miners remotely from there.