Something about Howard using the Universities super computer to mine Bitcoins and Sheldon developing his much superior Alt-Chain only to be 51% attacked would be awesome. (Not going to happen, I know)
If I knew how to contact the writers of the show, I would ask them about it.
I personally know a freelance writer that has done screenplays for The Big Bang Theory in the past, and I just called him and told him about this thread. He wouldn't give me any contact info for the show's internal personell, but he said that he liked the idea, and would write a screenplay with bitcoin in it, and submitt it to see if they will buy it. Such a process takes a great deal of time, though, so you can't expect to see it this season, if at all.