as long as you use 2fa in my opinion, your account / your wallet will be fine.
Tell that to all the people that lost coin at the exchanges and wallet sites that got hacked. I lost quite a lot (to me) at Cryptsy, a little dust at Inputs.io and got lucky that there was nothing in my Mt. Gox or BTC-e accounts.
A way bigger threat are actually the exchanges itself. You can use a strong password, 2FA etc etc. but all this doesn't matter when the operators of the exchanges itself are robbing you ... and you can't do anything about that, when you are a regular trader.
Can you explain in more detail how the operators of the exchanges are "robbing" you? If you're talking about the fees, then guess what: exchanges are also businesses, which are put up to make profit. You expect a company to spend thousands and thousands of dollars for their website and the huge database, employees, etc and put up their site without fees? Come on now.
Most of the so called hacks of exchanges that went bust are suspected of being inside jobs. Look up the ones I mentioned above. If the owner or employees are going to abscond with your coin then using 2FA isn't going to help you.